RVCL-S and CADASIL display distinct impaired vascular function
نویسندگان
چکیده
منابع مشابه
Impaired endothelial function of forearm resistance arteries in CADASIL patients.
BACKGROUND AND PURPOSE Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy, which mainly involves the brain causing stroke and dementia. Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, but studies of patients have been inconclusive so far. METHODS We examined p...
متن کاملImpaired vasoreactivity in mildly disabled CADASIL patients.
BACKGROUND AND PURPOSE CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a rare genetic disease caused by NOTCH3 gene mutations. A dysfunction in vasoreactivity has been proposed as an early event in the pathogenesis of the disease. The aim of this study was to verify whether endothelium dependent and/or independent function is altered in CA...
متن کاملImpaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.
BACKGROUND AND PURPOSE CADASIL is an inherited small-vessel disease responsible for lacunar strokes and cognitive impairment. The disease is caused by highly stereotyped mutations in Notch3, the expression of which is highly restricted to vascular smooth muscle cells (VSMCs). The underlying vasculopathy is characterized by degeneration of VSMCs and the accumulation of granular osmiophilic mater...
متن کاملDiagnostic criteria of vascular dementia in CADASIL.
BACKGROUND AND PURPOSE Subcortical ischemic vascular dementia (SIVD) is a major subtype of vascular dementia (VaD). Recently, the diagnostic criteria of VaD have been modified to encompass this entity. Application of these criteria in CADASIL, a genetic model of SIVD, may help to better assess their significance. The aim of this study was to compare different sets of diagnostic criteria of VaD ...
متن کاملDistinct Fuzzy Subgroups of a Dihedral Group of Order $2pqrs$ for Distinct Primes $p, , q, , r$ and $s$
In this paper we classify fuzzy subgroups of the dihedral group $D_{pqrs}$ for distinct primes $p$, $q$, $r$ and $s$. This follows similar work we have done on distinct fuzzy subgroups of some dihedral groups.We present formulae for the number of (i) distinct maximal chains of subgroups, (ii) distinct fuzzy subgroups and (iii) non-isomorphic classes of fuzzy subgroups under our chosen equival...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology
سال: 2018
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000006119